The immunogenicity of “novel” MART-1 and Tyrosinase class-II peptides was assessed in transgenic mice. Tyrosinase141-161 peptide was found to be immunogenic and endogenously processed in the HLA-DRβ1*0101 and HLADR β1*0401 transgenic mice with peptide specific production of IFNγ or IL-5 respectively. The MART-129-43 peptide was only found immunogenic in HLA-DRβ1*0101 mice.
Keywords: mhc class, peptides, cd t cells, vitamin e, dendritic cells
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