Nitrogen-Containing Heterocyclic Quinones: A Class of Potential Selective Antitumor Agents

Author(s): Laura Garuti, Marinella Roberti, Daniela Pizzirani

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 5 , 2007

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The development of prodrugs that are enzymatically activated into anticancer agents is a promising perspective in cancer therapy. Many nitrogen-containing quinoid heterocycles have been reported to show antitumor effect. The principal interest in these compounds lies on their potential to produce tumor-selective toxicity. Selectivity occurs by difference in oxygen tension between normal and tumor tissue and by levels of the required activating enzymes. In this review a summary of the most interesting heterocyclic quinones is given together with their biological property. SAR studies concerning the importance of some structural features will be described.

Keywords: Quinones, anticancer agents, tumor-selective toxicity, SAR, prodrugs, heterocycles

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Article Details

Year: 2007
Page: [481 - 489]
Pages: 9
DOI: 10.2174/138955707780619626
Price: $65

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