Abstract
To develop the newer pharmaceuticals and to spur the strong growth, being a general property of ‘handedness’, chirality plays a major role. The Easson-Stedman principle shows the differences in the biological activity between enantiomers resulted from selective reactivity of one enantiomer with its receptor. It helps to improve the pharmacokinetic properties and to remove undesirable side effects by virtue of the unique activity of enantiomers. Racemic switching and marketing drug combinations are used as tools for drug life-cycle management and to redevelop racemic mixtures as single enantiomers.
Keywords: Chirality, enantiomers, stereoselectivity, racemic switching, drug combination, pharmacokinetics
Mini-Reviews in Medicinal Chemistry
Title: Chirality - A New Era of Therapeutics
Volume: 7 Issue: 5
Author(s): Y. K. Agrawal, H. G. Bhatt, H. G. Raval, P. M. Oza and P. J. Gogoi
Affiliation:
Keywords: Chirality, enantiomers, stereoselectivity, racemic switching, drug combination, pharmacokinetics
Abstract: To develop the newer pharmaceuticals and to spur the strong growth, being a general property of ‘handedness’, chirality plays a major role. The Easson-Stedman principle shows the differences in the biological activity between enantiomers resulted from selective reactivity of one enantiomer with its receptor. It helps to improve the pharmacokinetic properties and to remove undesirable side effects by virtue of the unique activity of enantiomers. Racemic switching and marketing drug combinations are used as tools for drug life-cycle management and to redevelop racemic mixtures as single enantiomers.
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Cite this article as:
Agrawal K. Y., Bhatt G. H., Raval G. H., Oza M. P. and Gogoi J. P., Chirality - A New Era of Therapeutics, Mini-Reviews in Medicinal Chemistry 2007; 7 (5) . https://dx.doi.org/10.2174/138955707780619617
DOI https://dx.doi.org/10.2174/138955707780619617 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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