Chemistry and Biology of the Streptogramin A Antibiotics

Author(s): Fahim Ahmed, William A. Donaldson

Journal Name: Mini-Reviews in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Abstract:

The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene, oxazole, amide and ester functionality. The chemistry and biology of these valuable antimicrobial agents is covered.

Keywords: Antibiotics, biosynthetic origin, mode of action, total synthesis, synthetic studies

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [159 - 181]
Pages: 23
DOI: 10.2174/157019307780599315
Price: $65

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