Title: Chemistry and Biology of the Streptogramin A Antibiotics
VOLUME: 4 ISSUE: 2
Author(s):Fahim Ahmed and William A. Donaldson
Affiliation:Department of Chemistry,Marquette University, P. O. Box 1881, Milwaukee, WI 53201-1881 USA.
Keywords:Antibiotics, biosynthetic origin, mode of action, total synthesis, synthetic studies
Abstract: The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene, oxazole, amide and ester functionality. The chemistry and biology of these valuable antimicrobial agents is covered.
