Synthesis of Alkyl β-D-Glcp-(1 3)-[ β-D-Glcp-(1 6)]-β-D-Glcp-(1 6)-β-DGlucopyranosides with Anti-Tumor Activity

Author(s): Linsen Heng, Qianfei Zhao, Xiangdong Mei, Haibin Lv, Xiaohui Jiang, Jun Ning

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Concise and effective synthesis of alkyl tetrasaccharides were achieved from the key intermediates alkyl 2,3,4-tri-benzoyl-β-D-glucopyranoside (5) and 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1→3)- [2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1→6)]-2,4-di-O-acetyl-α-D-glucopyranosyl trichloroacetimidate (6), followed by deacylation. Bioassay of the inhibition of S180 noumenal tumors showed that alkyl tetrasaccharides could be employed as potential agent for cancer treatment.

Keywords: Carbohydrate, synthesis, oligosaccharide, glycosylation, trichloroacetimidate, anti-tumor

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Article Details

Year: 2007
Page: [142 - 145]
Pages: 4
DOI: 10.2174/157017807780414172
Price: $65

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