Synthesis of Pyrimidine-Annulated Heterocycles: Facile Sulfoxide Rearrangement of 1, 3-Dimethyl-5-(Aryloxybut-2-Ynylthio) Pyrimidine-2, 4-Dione (SUPPORTING DATA)

Author(s): Krishna C. Majumdar, Pradip K. Maji, Amarta K. Pal

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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A number of thieno [3,2-b] pyrimidines are regioselectively synthesized in good yields from 5-(4- aryloxybut-2-ynylthio) via sulfoxide rearrangement/tandem cyclization protocol by the treatment of the sulfides with one equivalent of m-CPBA in chloroform at 0-5°C with stirring the reaction mixture at room temperature for 2 h.

Keywords: 5-Mercaptouracil, tandem reaction, [2,3] sigmatropic rearrangement, [3,3] sigmatropic rearrangement, thienopyrimidine

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Article Details

Year: 2007
Page: [134 - 136]
Pages: 3
DOI: 10.2174/157017807780414127
Price: $65

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