A Simple and Efficient Synthesis of (S)- and (R)-1-(3-Methoxyphenyl) Ethylamine

Author(s): Meng Hu, Fu-Li Zhang, Mei-Hua Xie

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Abstract:

A novel one-pot asymmetric reductive amination of 3-methoxyacetophenone with (S)- or (R)-α- methylbenzylamine using the combination of Ti(OiPr)4/Raney-Ni/H2 has been reported. This procedure provides excellent yield and diastereomeric excess. After cleaving the chiral auxiliary, (S)- or (R)-1-(3- methoxyphenyl)ethylamine was obtained in high yield.

Keywords: (S)-1-(3-methoxyphenyl)ethylamine, (R)-1-(3-methoxyphenyl)ethylamine, asymmetric reductive amination, synthesis

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [126 - 128]
Pages: 3
DOI: 10.2174/157017807780414190
Price: $65

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