A novel one-pot asymmetric reductive amination of 3-methoxyacetophenone with (S)- or (R)-α- methylbenzylamine using the combination of Ti(OiPr)4/Raney-Ni/H2 has been reported. This procedure provides excellent yield and diastereomeric excess. After cleaving the chiral auxiliary, (S)- or (R)-1-(3- methoxyphenyl)ethylamine was obtained in high yield.
Keywords: (S)-1-(3-methoxyphenyl)ethylamine, (R)-1-(3-methoxyphenyl)ethylamine, asymmetric reductive amination, synthesis
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