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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

First Efficient Synthesis of Enantiopure Homoketopinic Acid

Author(s): Antonio Garcia Martinez, Santiago de la Moya Cerero, Enrique Teso Vilar, Amelia Garcia Fraile, Cristina Diaz Morillo and Tomas de las Casas Engel

Volume 4, Issue 2, 2007

Page: [123 - 125] Pages: 3

DOI: 10.2174/157017807780414208

Price: $65

Abstract

The first efficient synthesis of enantiopure homoketopinic acid, an interesting camphor derivative is firstly reported. The synthetic procedure uses 10-(triflyloxy)camphor as key electrophilic intermediate. The ability of 10-(triflyloxy)camphor to react selectively with a charged C-nucleophile (cyanide anion) without undergoing Grob fragmentation of the norbornane framework is also demonstrated.

Keywords: Bicyclic compounds, camphor derivatives, carboxylic acid, chiral agents


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