First Efficient Synthesis of Enantiopure Homoketopinic Acid

Author(s): Antonio Garcia Martinez, Santiago de la Moya Cerero, Enrique Teso Vilar, Amelia Garcia Fraile, Cristina Diaz Morillo, Tomas de las Casas Engel

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

Become EABM
Become Reviewer

Abstract:

The first efficient synthesis of enantiopure homoketopinic acid, an interesting camphor derivative is firstly reported. The synthetic procedure uses 10-(triflyloxy)camphor as key electrophilic intermediate. The ability of 10-(triflyloxy)camphor to react selectively with a charged C-nucleophile (cyanide anion) without undergoing Grob fragmentation of the norbornane framework is also demonstrated.

Keywords: Bicyclic compounds, camphor derivatives, carboxylic acid, chiral agents

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [123 - 125]
Pages: 3
DOI: 10.2174/157017807780414208
Price: $65

Article Metrics

PDF: 3