A Facile Regioselective Synthesis of Tetracyclic Sulphur Heterocycles by Tandem Thio-Claisen Rearrangement (SUPPORTING DATA)

Author(s): Krishna C. Majumdar, Nilasish Pal

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Thio-Claisen rearrangement of symmetrically substituted 1,4-but-2-ynes (3a,b and 4) exhibit tandem cyclization and afforded compounds 5a,b and 6 in good yields. These sulphides 3a,b and 4 were in turn prepared from commercially available thiophene. The key step in this transformation is tandem [3,3] sigmatropic rearrangement.

Keywords: Thio-Claisen rearrangement, mercaptothiophene, regioselectivity, tetracyclic sulphur compounds, tandem cyclisation

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Article Details

Year: 2007
Page: [120 - 122]
Pages: 3
DOI: 10.2174/157017807780414091
Price: $65

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