New Synthesis of 3-Aryl Isoquinolines by Pd-Catalyzed Suzuki Cross-Coupling

Author(s): Marco Franceschin, Stefano Frasca, Antonello Alvino, Armandodoriano Bianco

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Abstract:

A new synthetic approach to 3-aryl isoquinolines, based on the Pd-catalyzed Suzuki cross-coupling reaction, is reported. The described procedure represents an efficient method to prepare 3-aryl isoquinolines by reaction of a preformed 3-chloro isoquinoline with a phenylboronic acid, especially when the nitrogen atom is positively charged.

Keywords: Suzuki cross-coupling, Pd catalysis, 3-aryl isoquinolines

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [86 - 91]
Pages: 6
DOI: 10.2174/157017807780414217
Price: $65

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