Chiral Pyrrolidine-Based Salen Ligands for the Enantioselective Alkylation of Aromatic Aldehydes

Author(s): M. Elisa da Silva Serra, Dina Murtinho, Albertino Goth, A. M. d'A. Rocha Gonsalves

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Abstract:

A new type of Salen ligands derived from (2R, 3R)-N-benzyl-2,3-diaminopyrrolidine and aromatic hydroxyaldehydes was synthesized and tested in the enantioselective alkylation of aromatic aldehydes with diethylzinc, moderate selectivity being observed. This study represents the application of a new type of Zn- Salen ligands and opens the way to exploring these promising new structures in other enantioselective and biological processes.

Keywords: Pyrrolidine, diamine, Salen, diethylzinc, enantioselective, alkylation

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2007
Page: [80 - 85]
Pages: 6
DOI: 10.2174/157017807780414118
Price: $65

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