Fondaparinux: Pharmacology and Clinical Experience in Cardiovascular Medicine

Author(s): V. Toschi, M. Lettino

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 4 , 2007

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Fondaparinux is a synthetic, five-saccharide chain, AT-dependent, anti-FXa agent. Studies showed that fondaparinux acts in prevention and treatment of venous thromboembolism and in ischemic heart disease, without significant bleeding risk. The drug inhibits thrombin generation, has long half-life and can be administered once-daily without laboratory monitoring. It may be used in HIT treatment.

Keywords: Antithrombotic, factor Xa inhibitor, heparin, low molecular weight heparin, fondaparinux

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Article Details

Year: 2007
Page: [383 - 387]
Pages: 5
DOI: 10.2174/138955707780363819
Price: $65

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