Abstract
Fondaparinux is a synthetic, five-saccharide chain, AT-dependent, anti-FXa agent. Studies showed that fondaparinux acts in prevention and treatment of venous thromboembolism and in ischemic heart disease, without significant bleeding risk. The drug inhibits thrombin generation, has long half-life and can be administered once-daily without laboratory monitoring. It may be used in HIT treatment.
Keywords: Antithrombotic, factor Xa inhibitor, heparin, low molecular weight heparin, fondaparinux
Mini-Reviews in Medicinal Chemistry
Title: Fondaparinux: Pharmacology and Clinical Experience in Cardiovascular Medicine
Volume: 7 Issue: 4
Author(s): V. Toschi and M. Lettino
Affiliation:
Keywords: Antithrombotic, factor Xa inhibitor, heparin, low molecular weight heparin, fondaparinux
Abstract: Fondaparinux is a synthetic, five-saccharide chain, AT-dependent, anti-FXa agent. Studies showed that fondaparinux acts in prevention and treatment of venous thromboembolism and in ischemic heart disease, without significant bleeding risk. The drug inhibits thrombin generation, has long half-life and can be administered once-daily without laboratory monitoring. It may be used in HIT treatment.
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Cite this article as:
Toschi V. and Lettino M., Fondaparinux: Pharmacology and Clinical Experience in Cardiovascular Medicine, Mini-Reviews in Medicinal Chemistry 2007; 7 (4) . https://dx.doi.org/10.2174/138955707780363819
DOI https://dx.doi.org/10.2174/138955707780363819 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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