Boronated DNA-Binding Compounds as Potential Agents for Boron Neutron Capture Therapy

Author(s): Ellen L. Crossley, Erin J. Ziolkowski, Jeffrey A. Coderre, Louis M. Rendina

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 3 , 2007


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Abstract:

Boron Neutron Capture Therapy (BNCT) is a binary cancer treatment that exploits the short range particles released from a nuclear fission reaction involving the non-radioactive 10B nucleus and low-energy (thermal) neutrons for the destruction of tumour cells. If boronated agents are targeted towards chromosomal DNA, the efficiency of BNCT is greatly enhanced. This article presents a concise review of DNA-binding compounds that have been functionalised with boron.

Keywords: Boron neutron capture therapy, boronated agent, carborane, DNA-targeting, boronic acid

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2007
Published on: 01 March, 2012
Page: [303 - 313]
Pages: 11
DOI: 10.2174/138955707780059808
Price: $65

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