Recent Advances in the Development of Hybrid Molecules/Designed Multiple Compounds with Antiamnesic Properties

Author(s): Michael Decker

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 3 , 2007


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Abstract:

Novel compounds have been developed that (in many cases) inhibit cholinesterases and concomitantly interact with at least one further pharmacological target, such as 5-HT3 or H3 receptors. But also enzymes like monoamine oxidase and the serotonin transporter have been targeted. Hybrid molecules can also incorporate antioxidant or neuronal Ca2+- channel-blocking structures.

Keywords: Hybrid molecules, Multiple ligands, AChE inhibitors, Serotonin transporter (SERT), monoamine oxidase (MAO), lipoic acid, 5-HT3 receptor, Ca2+-channel blockers

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2007
Page: [221 - 229]
Pages: 9
DOI: 10.2174/138955707780059817
Price: $65

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