Somatostatin sst4 Ligands: Chemistry and Pharmacology

Author(s): A. Michael Crider, Ken A. Witt

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 3 , 2007

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Several classes of compounds (thioureas, ureas, β-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.

Keywords: somatotropin release-inhibiting factor, Cortistatin, Nonpeptides, CNS disorders, TRPV1 receptor

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Article Details

Year: 2007
Page: [213 - 220]
Pages: 8
DOI: 10.2174/138955707780059880
Price: $65

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