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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Somatostatin sst4 Ligands: Chemistry and Pharmacology

Author(s): A. Michael Crider and Ken A. Witt

Volume 7, Issue 3, 2007

Page: [213 - 220] Pages: 8

DOI: 10.2174/138955707780059880

Price: $65

Abstract

Several classes of compounds (thioureas, ureas, β-glucosides, sulfonamides, and cyclic peptides) show enhanced binding affinity and selectivity at somatostatin subtype 4 receptors (sst4). Pharmacophore models have recently been proposed to explain receptor subtype selectivity. The chemistry and therapeutic potential of sst4 ligands will be the subject of this review.

Keywords: somatotropin release-inhibiting factor, Cortistatin, Nonpeptides, CNS disorders, TRPV1 receptor

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