A New 1,2,4-Triazole Acyclonucleosides: Synthesis and Biological Evaluation

Author(s): Smaail Radi, Hassan B. Lazrek

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 3 , 2007

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Abstract:

Two new regioisomers acyclonucleosides bearing 1,2,4-triazole rings as the base moiety were synthesised with aliphatic side chain [(2-acetoxyethoxy)methyl]-bromide under solid-liquid phase transfer catalysis (S.L.P.T.C.) and under silylation method. Biological evaluation of all product revealed they were inactive against various RNA and DNA viruses in cell cultures. Structure activity relationship studies (SAR) indicate that introduction of acyclovir arm in N1 or N2 position of 1,2,4-triazole has not any impact on the antiviral activity.

Keywords: Nucleoside, Triazole, Catalysis, Antiviral, Ribavirin, Acyclovir

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2007
Page: [212 - 214]
Pages: 3
DOI: 10.2174/157018007780077372
Price: $65

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