Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D

Author(s): Manu Sharma, Pritam Dev Sharma, Mohinder Pal Bansal, Jaswant Singh

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 3 , 2007

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Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.

Keywords: Lantadene D, Cytotoxicity, Antitumor, 12-O- Tetradecanoylphorbol-13 acetate (TPA), 7, 12-Dimethylbenz [a] anthracene (DMBA)

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Article Details

Year: 2007
Page: [201 - 206]
Pages: 6
DOI: 10.2174/157018007780077471
Price: $65

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