Does Calprotectin Represent a Regulatory Factor in Host Defense or a Drug Target in Inflammatory Disease?

Author(s): M. E. Baldassarre, M. A. Altomare, M. Fanelli, D. Carbone, G. Di Bitonto, A. Mautone, N. Laforgia

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 7 , Issue 1 , 2007

Become EABM
Become Reviewer
Call for Editor


Calprotectin, a protein composed by two subunits of 8 and 14 kD respectively, is released by neutrophils in the biological fluids under inflammatory states. For instance, detection of calprotectin in faeces represents a diagnostic tool in the case of inflammatory bowel disease. Quite interestingly, calprotectin is increased in the stool of healthy newborns from day three up to day thirty and, physiologically, this increase may be interpreted as a defense mechanism against yeast and fungi. Therapeutic attempts at inhibiting the deleterious effect of calprotectin have been experimentally made by using lycoricinidol. This natural compound is able to hamper the calprotectin-induced apoptosis on the one hand. On the other hand, the same compound plays a prophylactic role in the course of experimental arthritis in rats.

Keywords: Calprotectin, inflammatory bowel disease, newborns, lycoricidinol

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Page: [1 - 5]
Pages: 5
DOI: 10.2174/187153007780059441

Article Metrics

PDF: 25