Loop Gain and Sleep Disordered Breathing

Author(s): Kingman P. Strohl, Motoo Yamauchi, Thomas E. Dick

Journal Name: Current Respiratory Medicine Reviews

Volume 3 , Issue 1 , 2007

Become EABM
Become Reviewer
Call for Editor


There is a close relationship among the types of sleep apnea (central, obstructive, and mixed) in regard to both the pathogenesis and in the clinical management of sleep apnea syndromes. This review will recount the rationale for the use of animal models in understanding intermediate traits, such as the ventilatory responses to hypoxia and reoxygenation, seen with human sleep apnea. One feature of particular interest will be the dynamic responses of the control system, specifically the instability over time that could operate to produce repetitive apneas. The recurrent nature of clinically significant sleep apnea can be understood in terms of feedback control, or “loop gain”. We will discuss findings in a mouse model for recurrent apneas and propose that there exist genetic mechanisms that could determine loop gain in the respiratory control system.

Keywords: Sleep apnea, animal model, hypoxia, respiratory control

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Page: [85 - 92]
Pages: 8
DOI: 10.2174/157339807779941794

Article Metrics

PDF: 11