Modern Pathology: Protein Mis-Folding and Mis-Processing in Complex Disease

Author(s): Ahmed Fadiel, Kenneth D. Eichenbaum, Adel Hamza, Orkon Tan, Hae H. Lee, Frederick Naftolin

Journal Name: Current Protein & Peptide Science

Volume 8 , Issue 1 , 2007

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Electrostatic and electrochemical properties of bio-molecules, such as proteins, are governed by energy parameters that are, in part dependent on its folding. Disruption of this process can lead to the development of complex, multisystem diseases whose presentation may be organ-dependent. Examples include cystic fibrosis, alpha-1 antitrypsin deficiency, and Alzheimer disease. In addition to explaining exotic pathologic syndromes, an understanding of protein folding mechanisms may facilitate the understanding of less complex diseases and allow the development of novel therapeutic approaches.

Keywords: Protein folding, protein mis-folding, proteomics, drug targeting, endoplasmic reticulum, disease etiology

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Article Details

Year: 2007
Page: [29 - 37]
Pages: 9
DOI: 10.2174/138920307779941532

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