Development of Core-Corona Type Polymeric Nanoparticles as an Anti-HIV-1 Vaccine

Author(s): Xin Wang, Takami Akagi, Mitsuru Akashi, Masanori Baba

Journal Name: Mini-Reviews in Organic Chemistry

Volume 4 , Issue 1 , 2007

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We developed a novel technology for core-corona polymeric nanoparticles having hydrophilic polymer chains with functional groups. Polystyrene nanoparticles immobilized with the mannose-specific lectin concanavalin A could efficiently capture human immunodeficiency virus type 1 (HIV-1) particles and gp120 antigens on their surface. Since the antigen-capturing nanoparticles were capable of inducing humoral and cellular immune responses to HIV-1, they could be developed as a mucosal vaccine against HIV-1 infection.

Keywords: Polystyrene nanoparticles, concanavalin A, HIV-1, mucosal vaccine

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Article Details

Year: 2007
Page: [51 - 59]
Pages: 9
DOI: 10.2174/157019307779815857

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PDF: 9