Inhibiting Protein-Protein Interactions as an Emerging Paradigm for Drug Discovery

Author(s): J. A. Gerrard, C. A. Hutton, M. A. Perugini

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 7 , Issue 2 , 2007

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Association of proteins into homo- and hetero-oligomers plays an important role in a plethora of biological phenomena. Inhibition of these interactions is increasingly recognized as a valuable new direction in drug design. In this mini-review we consider inhibition of protein misfolding and aggregation, molecules that disrupt enzyme quaternary structure, and signaling inhibitors, as emerging drugs.

Keywords: Protein-protein interactions, inhibitor, amyloid, HIV, drug design, small molecule-protein interaction

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Article Details

Year: 2007
Page: [151 - 157]
Pages: 7
DOI: 10.2174/138955707779802561
Price: $65

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