Title: BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury
VOLUME: 4 ISSUE: 2
Author(s):Roy Asaf, Shany Blum, Rachel Miller-Lotan and Andrew P. Levy
Affiliation:Technion Faculty of Medicine, Haifa, 31096, Israel.
Keywords:Diabetes, Myocardial ischemia-reperfusion, Oxidative stress, BXT-51072
Abstract: Oxidative stress is responsible for myocardial injury occurring after ischemia and reperfusion (IR) and has been shown to be modulated by the Haptoglobin (Hp) genotype. In this manuscript we demonstrate that the antioxidant BXT -51072, a glutathione peroxidase synthetic mimic, provides protection against IR injury in a Hp genotype dependent fashion.