Title: Synthesis and Antiparasitic Activity Against Trypanosoma cruzi and Leishmania amazonensis of Chlorinated 1,7- and 1,8-Naphthyridines
VOLUME: 4 ISSUE: 2
Author(s):Luiz Everson da Silva, Antonio Carlos Joussef, Leticia Kramer Pacheco, Danielle Bibas Legat Albino, Anita Mauricio Camilo Duarte, Mario Steindel and Ricardo Andrade Rebelo
Affiliation:Universidade Federal de Mato Grosso, Departamento de Quimica, Av. Fernando Correa da Costa,Coxipo, Cuiaba- Mato Grosso, Cep 78060-900, Brazil.
Keywords:Chloronaphthyridines, Antiparasitic, Trypanocidal and Leishmanicidal activities
Abstract: The leishmanicidal and trypanocidal activities of chlorinated 1,7- and 1,8-naphthyridines were evaluated against cultured of L. amazonensis promastigote and T. cruzi epimastigote forms. Active compounds were also tested against blood trypomastigotes and their toxicity to Vero cells. Among the compounds evaluated 10 was the most active against L. amazonensis promastigotes and T. cruzi epimastigotes, IC50= 8.6 μM and IC50 =20.4 μM, respectively.
