Title: Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study
VOLUME: 4 ISSUE: 2
Author(s):Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto and Stefano Moro
Affiliation:Molecular Modeling Section, Department of Pharmaceutical Sciences, University of Padova,Via Marzolo, 5 - 35131 Padova, Italy.
Keywords:3D-QSAR, Response Surface Analysis, Adenosine receptors
Abstract: 3D-QSAR methodologies represent a useful, widespread tool in drug discovery and optimisation. Here we introduce an alternative QSAR tool for model generation: the non-linear Response Surface Analysis, that finds at present great application in Design of Experiment for optimizing drug production processes. Binding affinity estimation of human A3 adenosine receptor antagonists is considered as key study.
