Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study

Author(s): Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto, Stefano Moro

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 2 , 2007

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3D-QSAR methodologies represent a useful, widespread tool in drug discovery and optimisation. Here we introduce an alternative QSAR tool for model generation: the non-linear Response Surface Analysis, that finds at present great application in Design of Experiment for optimizing drug production processes. Binding affinity estimation of human A3 adenosine receptor antagonists is considered as key study.

Keywords: 3D-QSAR, Response Surface Analysis, Adenosine receptors

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Article Details

Year: 2007
Page: [122 - 127]
Pages: 6
DOI: 10.2174/157018007779422460
Price: $65

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