Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study

Title: Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study

Volume: 4 Issue: 2

Author(s): Magdalena Bacilieri, Chosei Kaseda, Giampiero Spalluto and Stefano Moro

Affiliation:

Keywords: 3D-QSAR, Response Surface Analysis, Adenosine receptors

Abstract: 3D-QSAR methodologies represent a useful, widespread tool in drug discovery and optimisation. Here we introduce an alternative QSAR tool for model generation: the non-linear Response Surface Analysis, that finds at present great application in Design of Experiment for optimizing drug production processes. Binding affinity estimation of human A3 adenosine receptor antagonists is considered as key study.

Cite this article as:

Bacilieri Magdalena, Kaseda Chosei, Spalluto Giampiero and Moro Stefano, Response Surface Analysis as Alternative 3D-QSAR Tool: Human A3 Adenosine Receptor Antagonists as a Key Study, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422460