Abstract
We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.
Keywords: Gene delivery, Cationic polymer, Transfection
Letters in Drug Design & Discovery
Title: Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells
Volume: 4 Issue: 2
Author(s): Chandrashekhar Chittimalla, Deniz Dalkara and Guy Zuber
Affiliation:
Keywords: Gene delivery, Cationic polymer, Transfection
Abstract: We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.
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Cite this article as:
Chittimalla Chandrashekhar, Dalkara Deniz and Zuber Guy, Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422569
DOI https://dx.doi.org/10.2174/157018007779422569 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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