Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells

Author(s): Chandrashekhar Chittimalla, Deniz Dalkara, Guy Zuber

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 2 , 2007

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We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.

Keywords: Gene delivery, Cationic polymer, Transfection

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Article Details

Year: 2007
Page: [92 - 98]
Pages: 7
DOI: 10.2174/157018007779422569
Price: $65

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