Title: Design, Synthesis and Evaluation of a Novel Polymer for Gene Delivery to Mammalian Cells
VOLUME: 4 ISSUE: 2
Author(s):Chandrashekhar Chittimalla, Deniz Dalkara and Guy Zuber
Affiliation:Laboratoire de Chimie GenetiqueCNRS UMR 7175- LC1- Faculte de Pharmacie, Universite Louis Pasteur, Strasbourg I, 74 route du Rhin, BP 60024, 67401 Illkirch Cedex,France.
Keywords:Gene delivery, Cationic polymer, Transfection
Abstract: We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.
