Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies

Title: Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies

Volume: 4 Issue: 2

Author(s): Andrew Tsotinis, Marilena Vlachou, Maria Gerasimopoulou, Aphrodite Eikosipentaki, Constantine Ioannidis, Anna Klouvidaki, Pandelis A. Afroudakis, Dimitri Moreau and Christos Roussakis

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Keywords: Symmetrical pyrrolo[2,3-f]quinolines, Synthesis, Cytotoxicity, Drug delivery

Abstract: The synthesis, pharmacological properties and delivery characteristics in simulated aqueous gastric fluid of a series of symmetrical nitrogenated C2-substituted pyrrolo[2,3-f]quinolines are described. The cytotoxicity of the target molecules (5a-h) was evaluated in the human non-small lung cancer cell line NSCLCN16- L16 in vitro. One compound (5e) showed sufficient activity (IC50 = 26.4 μM) and satisfactory release characteristics from solid pharmaceutical formulations.

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Tsotinis Andrew, Vlachou Marilena, Gerasimopoulou Maria, Eikosipentaki Aphrodite, Ioannidis Constantine, Klouvidaki Anna, Afroudakis A. Pandelis, Moreau Dimitri and Roussakis Christos, Symmetrical Derivatives of C2-Substituted Pyrrolo[2,3-f]quinolines:Synthesis, Cytotoxicity and Drug Delivery Studies, Letters in Drug Design & Discovery 2007; 4 (2) . https://dx.doi.org/10.2174/157018007779422488