Discovery of Inhibitors of Protein-Protein Interactions from Combinatorial Libraries

Author(s): Maria J. Vicent, Enrique Perez-Paya, Mar Orzaez

Journal Name: Current Topics in Medicinal Chemistry

Volume 7 , Issue 1 , 2007

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Protein-protein interactions play a central role within numerous processes in the cell. The relevance of the processes in which this type of interactions are implicated make them responsible for many pathological situations. In the last decade protein-protein interfaces have shown their potential as new drug targets, and combinatorial chemistry has been defined as a useful tool in this line. This review gives a global vision of the actual situation of combinatorial chemistry, highlighting its applicability to high-throughput drug discovery and giving some crucial examples of its contribution to find modulators of protein-protein interactions.

Keywords: HIV protease, Integrin alpha2 I domain, Combinatorial Chemistry, Apoptosis, Rabies Virus, MMP-2

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Article Details

Year: 2007
Page: [83 - 95]
Pages: 13
DOI: 10.2174/156802607779318307

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