Title: Amphibian Secretions for Drug Discovery Studies: A Search for New Antiparasitic and Antifungal Compounds
VOLUME: 4 ISSUE: 1
Author(s):Andre Gustavo Tempone, Marcia de Souza Carvalho Melhem, Frederico Oliveira Prado, Gabriela Motoie, Roberto Mitsuyoshi Hiramoto, Marta Maria Antoniazzi, Celio Fernando Baptista Haddad and Carlos Jared
Affiliation:Lab. Toxinologia Aplicada,Departamento de Parasitologia, Instituto Adolfo Lutz Av. Dr. Arnaldo 355,8° andar CEP 01246-000 Sao Paulo Brasil.
Keywords:Peptides, Secretions, Amphibians, Leishmania, Trypanosoma, Antimicrobial
Abstract: The antiparasitic and antifungal activities of nine amphibian skin secretions were studied in different in vitro models. Seven secretions presented a considerable antiprotozoan activity and one showed promising results against Candida sp. These results can be the basis for the development of new drugs, especially for neglected parasitic diseases.
