Design, Synthesis and Evaluation of Peroxisome Proliferator-Activated Receptor α/βDual Agonists for the Treatment of Type 2 Diabetes

Author(s): Saibal Kumar Das, Chandrasekhar Abbineni, Krovvidi Venkata Lakshmi Narasimha Rao, Javed Iqbal, Ravi Krishna Babu, Ranjan Chakrabarti

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 1 , 2007

Become EABM
Become Reviewer
Call for Editor


The design, synthesis and evaluation of several dual PPARα/γ agonists with three different heterocycles, viz. pyrazolo[4,3-d]pyrimidin-7-one, quinazolin-4-one and benzo[e][1,3]oxazine-4-one for the treatment of type 2 diabetes and associated dyslipidemia are described. Among them, compound 5cb was found to possess a potent dual PPARα/β agonist property. It significantly reversed diabetic hyperglycemia while improving overall lipid homeostasis in preclinical animal models.

Keywords: PPAR, Diabetes, Synthesis, Ethyl 3-(4-aminophenyl)-2-ethoxypropionate, Dyslipidemia and Plasma glucose

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Page: [27 - 32]
Pages: 6
DOI: 10.2174/157018007778992883
Price: $65

Article Metrics

PDF: 31