Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application

Yasuyuki  Shimada and   Fumio  Yamamoto

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Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application

Author(s): Yasuyuki Shimada, Fumio Yamamoto

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Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 1 , 2007

DOI : 10.2174/157018007778992838

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Abstract:

The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.

Keywords: Na+/H+ exchanger, Review, Human, Surgery, Cariporide, Eniporide

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Letters in Drug Design & Discovery

Title: Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application

VOLUME: 4 ISSUE: 1

Author(s):Yasuyuki Shimada and Fumio Yamamoto

Affiliation:Department of Cardiovascular Surgery, Yuri-Kumiai General Hospital, 38, Ieno-ushiro,Aza, Kawaguchi, Yuri-Honjo, AKITA 015-8511 Japan.

Keywords:Na+/H+ exchanger, Review, Human, Surgery, Cariporide, Eniporide

Abstract: The Na+-HCO3 - symport plays as significant role as the Na+/H+ exchanger in ischemia/reperfusion injury. Under bicarbonate free conditions, however, the Na+-HCO3 - symport does not work, and so the protective efficacy of Na+/H+ exchanger inhibitors is overestimated. We discuss the reasons for the inconsistencies in studies of the Na+/H+ exchanger.

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Yasuyuki Shimada and Fumio Yamamoto, “ Sodium Proton Exchanger Inhibitor in Ischemia/Reperfusion Injury in the Heart Surgery: Controversy in Clinical Application”, Letters in Drug Design & Discovery (2007) 4: 9. https://doi.org/10.2174/157018007778992838

DOI https://doi.org/10.2174/157018007778992838	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X

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VOLUME: 4
ISSUE: 1
Year: 2007

Page: [9 - 14]
Pages: 6
DOI: 10.2174/157018007778992838

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