Proteolytic Degradation of the Amyloid β-Protein: The Forgotten Side of Alzheimers Disease

Author(s): Malcolm A. Leissring

Journal Name: Current Alzheimer Research

Volume 3 , Issue 5 , 2006

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Proteases have long played a central role in the molecular pathogenesis of Alzheimer ’ s disease (AD), yet proteases that degrade the amyloid β-protein (Aβ) itself were largely ignored until only quite recently. Today, we know that Aβ-degrading proteases are critical regulators of brain Aβ levels in vivo, with evidence accumulating that their dysfunction may play a role in the etiology of AD. This review explores the historical factors that obscured this important aspect of amyloidogenesis, and discusses the many fresh insights it offers into the causes of and potential treatments for AD.

Keywords: Alzheimer's disease, proteases, amyloid, amyloidogenesis, catabolism

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Article Details

Year: 2006
Page: [431 - 435]
Pages: 5
DOI: 10.2174/156720506779025206
Price: $65

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