Abstract
Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.
Keywords: Glycosylation, cancer, glycosyltransferase, synthesis, vaccine, immunotherapy, carbohydrate
Mini-Reviews in Medicinal Chemistry
Title: Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer
Volume: 6 Issue: 12
Author(s): Teresa Freire, Sylvie Bay, Sophie Vichier-Guerre, Richard Lo-Man and Claude Leclerc
Affiliation:
Keywords: Glycosylation, cancer, glycosyltransferase, synthesis, vaccine, immunotherapy, carbohydrate
Abstract: Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.
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Freire Teresa, Bay Sylvie, Vichier-Guerre Sophie, Lo-Man Richard and Leclerc Claude, Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer, Mini-Reviews in Medicinal Chemistry 2006; 6 (12) . https://dx.doi.org/10.2174/138955706778992996
DOI https://dx.doi.org/10.2174/138955706778992996 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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