Carbohydrate Antigens: Synthesis Aspects and Immunological Applications in Cancer

Author(s): Teresa Freire, Sylvie Bay, Sophie Vichier-Guerre, Richard Lo-Man, Claude Leclerc

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 12 , 2006

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Tumor Associated Carbohydrate Antigens (TACAs) constitute powerful tools as tumor markers and as targets for anticancer immunotherapy. In this review, methods of production of glycopeptide-based vaccines, as well as results of preclinical and clinical studies in cancer patients are discussed.

Keywords: Glycosylation, cancer, glycosyltransferase, synthesis, vaccine, immunotherapy, carbohydrate

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Article Details

Year: 2006
Page: [1357 - 1373]
Pages: 17
DOI: 10.2174/138955706778992996
Price: $65

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