Title: Carbohydrate-Based Scaffolds in Drug Discovery
VOLUME: 6 ISSUE: 12
Author(s):Bernd Becker, Glenn C. Condie, Giang Thanh Le and Wim Meutermans
Affiliation:Alchemia Ltd, PO Box 6242, Upper Mt Gravatt, Qld 4122, Australia.
Keywords:Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics
Abstract: Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.
