Carbohydrate-Based Scaffolds in Drug Discovery

Author(s): Bernd Becker, Glenn C. Condie, Giang Thanh Le, Wim Meutermans

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 12 , 2006

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Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

Keywords: Carbohydrates, combinatorial chemistry, carbohydrate scaffolds, mimetics

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Article Details

Year: 2006
Page: [1299 - 1309]
Pages: 11
DOI: 10.2174/138955706778993003
Price: $65

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