Abstract
Adverse extracellular matrix (ECM) remodeling contributes to fibrotic disorders in the kidney, lung, and heart. Matrix metalloproteinases (MMPs) are key enzymes regulating ECM turnover, and MMP inhibition attenuates remodeling. Recent technological developments allow MMP-substrate relationships to be identified and explored as novel therapeutic targets. This review summarizes current and novel strategies to block MMP activity.
Keywords: Matrix metalloproteinases, extracellular matrix, MMP inhibitors, mechanism-based inhibition, proteomics, remodeling, fibrosis
Mini-Reviews in Medicinal Chemistry
Title: Novel Strategies to Delineate Matrix Metalloproteinase (MMP)-Substrate Relationships and Identify Targets to Block MMP Activity
Volume: 6 Issue: 11
Author(s): M. L. Lindsey
Affiliation:
Keywords: Matrix metalloproteinases, extracellular matrix, MMP inhibitors, mechanism-based inhibition, proteomics, remodeling, fibrosis
Abstract: Adverse extracellular matrix (ECM) remodeling contributes to fibrotic disorders in the kidney, lung, and heart. Matrix metalloproteinases (MMPs) are key enzymes regulating ECM turnover, and MMP inhibition attenuates remodeling. Recent technological developments allow MMP-substrate relationships to be identified and explored as novel therapeutic targets. This review summarizes current and novel strategies to block MMP activity.
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Cite this article as:
Lindsey L. M., Novel Strategies to Delineate Matrix Metalloproteinase (MMP)-Substrate Relationships and Identify Targets to Block MMP Activity, Mini-Reviews in Medicinal Chemistry 2006; 6 (11) . https://dx.doi.org/10.2174/138955706778742777
DOI https://dx.doi.org/10.2174/138955706778742777 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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