Adenosine-to-Inosine RNA Editing: Perspectives and Predictions

Author(s): Barry Hoopengardner

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 11 , 2006


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Abstract:

Adenosine-to-Inosine RNA editing introduces changes in RNA transcripts via a post-transcriptional mechanism, the hydrolytic deamination of adenosine (A) to inosine (I) which is interpreted as guanosine by cellular machineries. Adenosine deaminases that act on RNA (ADAR) enzymes catalyze editing in double-stranded (ds) RNA substrates.

Keywords: Adenosine, inosine, RNA, editing, drosophila, ion channel, convergence

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Article Details

VOLUME: 6
ISSUE: 11
Year: 2006
Published on: 01 March, 2012
Page: [1213 - 1216]
Pages: 4
DOI: 10.2174/138955706778742812
Price: $65

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