Advances in the Development of Inactivated Virus Vaccines

Author(s): Fausto Stauffer, Tatiana El-Bacha, Andrea T. Da Poian

Journal Name: Recent Patents on Anti-Infective Drug Discovery
Continued as Recent Advances in Anti-Infective Drug Discovery

Volume 1 , Issue 3 , 2006

Become EABM
Become Reviewer
Call for Editor


Vaccine discovery stands out as one of the public health interventions that has achieved the greatest impact in worlds health. Vaccination is the most effective means of disease prevention, especially for viral infections. Starting with the use of smallpox vaccine by Jenner in the late 1700s, the technology for vaccine development has seen numerous advances. Currently, vaccines available for human viral illness are based on live attenuated (e.g. measles, mumps, and rubella), inactivated (e.g. hepatitis A) and recombinant (e.g. hepatitis B) viruses. Among these, inactivated vaccines are known for their easy production and safety. The present article reviews the literature and patents related to the mechanisms used for viral inactivation, mainly chemical and physical procedures, including the novel strategies that are currently being explored and that have been recently patent protected.

Keywords: Virus, viral inactivation, chemical methods, physical methods, vaccines

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2006
Page: [291 - 296]
Pages: 6
DOI: 10.2174/157489106778777673
Price: $65

Article Metrics

PDF: 16