Abstract
The guanidinium group is a typical functional group in molecules with physiological or biological activity. Its geometry and physiochemical properties are of importance for molecular recognition processes. We discuss in this review modern synthetic methods for the introduction of the guanidinium group and focus our survey on examples from natural product synthesis and drug synthesis. The presented methods are sufficiently mild and selective to allow guanidylation of more complex structures.
Keywords: Guanidinium, urea, thiourea, guanidinylation reagents, natural products, drug synthesis
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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