Synthesis and Biological Activity of Akt/PI3K Inhibitors

Author(s): C. Redaelli, F. Granucci, L. De Gioia, L. Cipolla

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 10 , 2006


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Abstract:

Phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase B (PKB or Akt) pathways regulate important cellular processes and are related to a number of human pathologies, such as cancer. The development of kinase inhibitors, with particular attention to small molecule analogues of natural phosphoinositides for pathway interruption and therapeutic applications will be reviewed.

Keywords: Kinases, Akt, PI3K, cancer, kinase inhibitors, allosteric inhibitors, phosphatidylinositol, phosphatidylinositol analogues

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Article Details

VOLUME: 6
ISSUE: 10
Year: 2006
Page: [1127 - 1136]
Pages: 10
DOI: 10.2174/138955706778560139
Price: $65

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