Recombinant Factor VIIA, its Clinical Properties, and the Tissue Factor Pathway of Coagulation

Author(s): Timothy J. Bosinski, Ali A. El Solh

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 10 , 2006


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Abstract:

Recombinant factor VIIa (rFVIIa) is a synthetic coagulation protease that is structurally similar to humanderived plasma FVIIa. Pharmacologic doses of rFVIIa have been shown to enhance thrombin generation and assist in forming stable fibrin plugs at the site of injury. Recombinant factor VIIa appears to emerge as a valuable treatment alternative for the treatment of bleeding episodes and for achieving hemostasis post surgery in those with bleeding disorders.

Keywords: Recombinant factor VIIa, tissue factor, hemostasis, coagulation

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Article Details

VOLUME: 6
ISSUE: 10
Year: 2006
Published on: 01 March, 2012
Page: [1111 - 1117]
Pages: 7
DOI: 10.2174/138955706778560201
Price: $65

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