Abstract
Asthma is a chronic inflammatory disease of the airways associated with variable airflow obstruction and increased responsiveness to a variety of stimuli. Arachidonic acid metabolites play an important role in the pathophysiology of asthma and in this review we examine the major products of the lipoxygenase and cycloxygenase pathways, their effects on the airways and the current strategies used to target them.
Keywords: Arachidonic acid, Phospholipase A2, Lipoxygenase, Thromboxanes, Cycloxygenase
Letters in Drug Design & Discovery
Title: Eicosanoids as Therapeutic Targets in Asthma
Volume: 3 Issue: 9
Author(s): P. Rastogi and J. McHowat
Affiliation:
Keywords: Arachidonic acid, Phospholipase A2, Lipoxygenase, Thromboxanes, Cycloxygenase
Abstract: Asthma is a chronic inflammatory disease of the airways associated with variable airflow obstruction and increased responsiveness to a variety of stimuli. Arachidonic acid metabolites play an important role in the pathophysiology of asthma and in this review we examine the major products of the lipoxygenase and cycloxygenase pathways, their effects on the airways and the current strategies used to target them.
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Cite this article as:
Rastogi P. and McHowat J., Eicosanoids as Therapeutic Targets in Asthma, Letters in Drug Design & Discovery 2006; 3 (9) . https://dx.doi.org/10.2174/157018006778341165
DOI https://dx.doi.org/10.2174/157018006778341165 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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