Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis

Author(s): Mark A. Lovell, William R. Markesbery

Journal Name: Current Alzheimer Research

Volume 3 , Issue 4 , 2006

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Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimers disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4-hydroxy-2-nonenal, acrolein) lead to cell death through apoptosis or programmed cell death in AD. This review discusses current evidence supporting the role of oxidative stress/damage mediated apoptosis in in vitro models of neurodegeneration.

Keywords: anti-apoptotic proteins, oxidative damage, permeability transition pore (PTP), sodium/potassium-transporting ATPase, dependent anion channel (VDAC)

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Article Details

Year: 2006
Page: [359 - 364]
Pages: 6
DOI: 10.2174/156720506778249506
Price: $65

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