Anti-tumor Therapeutic Molecules that Target the Programmed Cell Death Machinery

Author(s): Iva Ivanovska, Clare N. Muhoro, Pablo M. Irusta

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 9 , 2006


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Abstract:

Apoptosis is a process that governs the elimination of unwanted, damaged, or infected cells in most organisms. Defects in its execution are associated with several diseases, including cancer. Herein, we discuss novel molecules with potential anti-tumor activity that target components of the apoptotic machinery, specifically Bcl-2 proteins, IAPs and caspases.

Keywords: Cancer, apoptosis, IAP, Caspases, Bcl-2

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Article Details

VOLUME: 6
ISSUE: 9
Year: 2006
Page: [1033 - 1042]
Pages: 10
DOI: 10.2174/138955706778195216
Price: $65

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