Modulation of Catalytic RNA Biological Activity by Small Molecule Effectors

Author(s): Anastassios Vourekas, Dimitra Kalavrizioti, Constantinos Stathopoulos, Denis Drainas

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 6 , Issue 9 , 2006

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Abstract:

Catalytic RNAs, known as ribozymes, act as true enzymes and are implicated in important biological processes, such as protein synthesis, mRNA splicing, transcriptional regulation and retroviral replication. Ribozymes are capable of serving as a new molecular target for a variety of drugs and as a reliable screening system for their biological activity.

Keywords: Ribozymes, RNase P, ribosome, drug target, aminoglycosides, macrolides, retinoids, calcipotriol

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Article Details

VOLUME: 6
ISSUE: 9
Year: 2006
Page: [971 - 978]
Pages: 8
DOI: 10.2174/138955706778195199
Price: $65

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