Regulatory T-Cells: Immunomodulators in Health and Disease

Author(s): Karen Scalzo, Magdalena Plebanski, Vasso Apostolopoulos

Journal Name: Current Topics in Medicinal Chemistry

Volume 6 , Issue 16 , 2006

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Regulation of immune responses is crucial in order to maintain immunological self-tolerance. This is maintained in the periphery by a number of cell types that have the capacity to control and regulate immune responses, thus preventing reactivity to self while monitoring appropriate, non-exuberant responses to non-self-antigens. The various mechanisms of regulation will be discussed in this review together with how this knowledge could be used to develop better drugs and treatments for various diseases.

Keywords: CD4+CD25+ regulatory cells, Tr1, Th3, immuno-modulatory drugs

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Article Details

Year: 2006
Page: [1759 - 1768]
Pages: 10
DOI: 10.2174/156802606778194262
Price: $65

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