Abstract
Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. The inhibitiory activity of methyl 3-{4-[2- [N-(4-methylbenzylphenyl)methyl,N-methylamino]ethoxy]phenyl} -2-methoxycarbonylpropionate (5b, IC50 = 0.0039 μM) and methyl 3-{4-[2-[N-bis(4-methoxy phenyl)methyl,N-methylamino]ethoxy]phenyl}-2- methoxycarbonylpropionate (5d, IC50 = 0.0027 μM) was higher than that of control drug captopril (IC50 = 0.0075 μM).
Keywords: ACE inhibitor, 2-methoxycarbonyl-3-phenyl propionate derivative, Hypertension
Letters in Organic Chemistry
Title: Methyl 2-Methoxycarbonyl-3-Phenylpropionate Derivatives: A New Type of Angiotensin Converting Enzyme Inhibitors
Volume: 3 Issue: 6
Author(s): Hui Guo, Bing Xie and Xiao-Hua Cai
Affiliation:
Keywords: ACE inhibitor, 2-methoxycarbonyl-3-phenyl propionate derivative, Hypertension
Abstract: Methyl 2-methoxycarbonyl-3-phenylpropionate derivatives were prepared, and their inhibitory activities for angiotensin converting enzyme (ACE) were evaluated. The inhibitiory activity of methyl 3-{4-[2- [N-(4-methylbenzylphenyl)methyl,N-methylamino]ethoxy]phenyl} -2-methoxycarbonylpropionate (5b, IC50 = 0.0039 μM) and methyl 3-{4-[2-[N-bis(4-methoxy phenyl)methyl,N-methylamino]ethoxy]phenyl}-2- methoxycarbonylpropionate (5d, IC50 = 0.0027 μM) was higher than that of control drug captopril (IC50 = 0.0075 μM).
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Cite this article as:
Guo Hui, Xie Bing and Cai Xiao-Hua, Methyl 2-Methoxycarbonyl-3-Phenylpropionate Derivatives: A New Type of Angiotensin Converting Enzyme Inhibitors, Letters in Organic Chemistry 2006; 3 (6) . https://dx.doi.org/10.2174/157017806777828484
DOI https://dx.doi.org/10.2174/157017806777828484 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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